Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Improving Translational Accuracy02:07

Improving Translational Accuracy

11.8K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.8K
Ribosome Profiling02:24

Ribosome Profiling

3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Heartbeat: a multimodal dataset of fetal echocardiography and clinical metadata for early detection of congenital heart disease.

Frontiers in cardiovascular medicine·2026
Same author

Journal international de bioethique et d'ethique des sciences·2026
Same author

Clostridium perfringens bacteremia secondary to tubo-ovarian abscess in a post-menopausal, immunocompetent female: a case report.

BMC infectious diseases·2026
Same author

Comparative validation of surgical phase recognition, instrument keypoint estimation, and instrument instance segmentation in endoscopy: Results of the PhaKIR 2024 challenge.

Medical image analysis·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

ContiMorph: An unsupervised learning framework for cardiac motion tracking with time-continuous diffeomorphism.

Medical image analysis·2026
Same journal

MedP-CLIP: Medical CLIP with region-aware prompt integration.

Medical image analysis·2026
Same journal

Multi-organ guided diagnosis of mild cognitive impairment via hierarchical alignment and knowledge distillation.

Medical image analysis·2026
Same journal

SUDA: Simultaneous unsupervised knowledge distillation and adaptation of foundation models for efficient pathological image analysis.

Medical image analysis·2026
Same journal

Beyond the LUMIR challenge: The pathway to foundational registration models.

Medical image analysis·2026
Same journal

Annotation-efficient medical image segmentation via cross-latent graphs and vector-quantized memory.

Medical image analysis·2026
查看所有相关文章

相关实验视频

Updated: Sep 9, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

892

完成基因表达预测基因基因表达预测数据

Daniela Ruiz1, Paula Cárdenas1, Leonardo Manrique1

  • 1Center for Research and Formation in Artificial Intelligence, Universidad de los Andes, Colombia, Carrera 1 No. 18a-12, Bogotá, 111711, Colombia.

Medical image analysis
|August 30, 2025
PubMed
概括
此摘要是机器生成的。

这项研究介绍了SpaRED,一个用于评估基因表达预测的数据库,以及SpaCKLE,一个显著提高数据准确性的模型. 这些进展旨在加强空间转录学研究和临床整合.

关键词:
基准值完成时间基因表达预测组织学空间转录学变压器视觉系统

更多相关视频

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

2.8K

相关实验视频

Last Updated: Sep 9, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

892
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

2.8K

科学领域:

  • 计算生物学
  • 基因组学
  • 生物技术

背景情况:

  • 空间转录组学将组织学与基因表达结合在一起,但面临着高成本和数据丢失等挑战.
  • 深度学习模型从组织学图像中预测基因表达,但由于数据集和协议不一致,缺乏标准化的评估.

研究的目的:

  • 为评估基因表达预测模型建立标准化资源.
  • 为完成基因表达数据开发一个先进的模型.
  • 为空间转录学研究创建一个全面的基准.

主要方法:

  • 在SpaRED数据库中整理了26个公共数据集,用于标准化模型评估.
  • 开发了基于变压器的基因表达完成模型SpaCKLE.
  • 建立了SpaRED基准,对原始和已完成的数据进行了八种预测模型的评估.

主要成果:

  • SpaRED为空间转录学模型评估提供了一个标准化资源.
  • 在基因表达完成过程中,SpaCKLE 将平均二次误差降低了82. 5%.
  • 在所有评估的基因表达预测模型中,SpaCKLE显著提高了性能.

结论:

  • SpaRED数据库和SpaCKLE模型提供了一个全面的基因表达预测基因图像的基准和改进的方法.
  • 这些贡献使空间转录学研究更加可靠和可访问,为临床应用铺平了道路.