2-单糖醇中的脂肪酸成分调节GLP-1的分泌
Yui Funatsu1, Nozomi Takahashi2, Yukiko Yamazaki2
1Wellness Science Labs, Meiji Holdings Co., Ltd., 1-29-1 Nakakuni, Hachioji, Tokyo, 192-0919, Japan; Department of Agricultural Chemistry, School of Agriculture, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki-shi, Kanagawa, 214-8571, Japan.
通过GPR119和GPR40,2- 棕甲基糖醇显著增强类似葡萄糖-1 (GLP-1) 的分泌. 油脂中的位置性脂肪酸分布也会影响GLP-1的释放,这表明2-PG是代谢调节的营养策略.
科学领域:
- 代谢调节
- 内分泌学
- 营养科学
背景情况:
- 葡萄糖类-1 (GLP-1) 是一种关键的肠道激素,可以调节血糖,食欲和β细胞功能.
- 之前的研究发现2-oleoylglycerol (2-OG) 是GLP-1分泌剂.
研究的目的:
- 选2-单糖醇 (2-MAG) 增加GLP-1的分泌.
- 研究参与2 - 棕甲基 (2-PG) 诱导GLP-1释放的受体.
- 评估三糖醇 (TAG) 中脂肪酸位置分布对GLP-1分泌的生理影响.
主要方法:
- 在STC-1细胞中选8个2-MAG.
- 使用G蛋白结合受体119 (GPR119) 和G蛋白结合受体40 (GPR40) 抗体进行药理抑制.
- 给小鼠施用具有不同sn-2脂肪酸成分的油,并测量门静脉GLP-1水平.
主要成果:
- 在经过测试的2- MAG中,2- 棕糖醇 (2- PG) 被确定为最强的GLP- 1分泌增强剂.
- 由2-PG诱导的GLP-1分泌被GPR119和GPR40抗剂减弱,这表明2-PG激活了GPR40.
- 与食 sn-2 油脂或 sn-1/sn-3 油脂相比,用 sn-2 油脂丰富的小鼠的GLP-1 水平显著更高.
结论:
- 2 - 棕甲基糖醇 (2-PG) 是一种强大的GLP-1分泌增强剂,通过GPR119和GPR40起作用.
- 脂肪酸在TAG中的位置分布对体内GLP-1分泌有重大影响.
- 2-PG是旨在调节新陈代谢的营养策略的一个有希望的目标.
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