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Updated: Sep 9, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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Published on: September 25, 2017

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通过阿尔多- 基因还原酶1C3调节的亚还原激活弗鲁尼特拉塞

Cátia F Marques1, Maya Narang2, Kim A Sharp2

  • 1Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Drug metabolism and disposition: the biological fate of chemicals
|August 30, 2025
PubMed
概括

阿尔多基因还原酶1C3 (AKR1C3) 将弗鲁尼特拉塞帕代谢成反应性中间体,可能增加药物的毒性. 这表明AKR1C3和AKR1C2会影响flunitrazepam的反应.

关键词:
阿尔多基因减少酶药物代谢肝瘤细胞质谱学

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