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在CASPR2抗体疾病谱中的神经性疼痛:系统性审查

Sara Cornacchini¹, Massimiliano Ugo Verza¹, Mattia Schiavolin¹

¹Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.

Journal of neuroimmunology

|August 30, 2025

概括

神经性疼痛可能是接触素相关蛋白类2 (CASPR2) 抗体疾病的孤立症状. 早期免疫疗法,特别是二线治疗,在治疗疼痛和实现缓解方面表现出很高的效果.

科学领域:

神经学
免疫学
治疗疼痛的方法

背景情况:

与接触蛋白相关的类似蛋白2 (CASPR2) 抗体主要与获得的神经肌,边缘脑炎和莫凡综合征有关.
神经病痛是一种新出现的临床表现,但其在CASPR2抗体疾病中的特征需要进一步定义.
本研究介绍了与CASPR2抗体相关的单独神经性疼痛病例,并回顾了现有文献.

研究的目的:

在CASPR2抗体疾病中描述神经病痛表现.
在此背景下评估免疫治疗和神经性疼痛的症状治疗的有效性.
强调在没有解释的神经病痛的患者中查CASPR2抗体的重要性.

主要方法:

根据PRISMA指南,使用MEDLINE,Embase和Cochrane数据库进行了系统审查.
根据CARE的指导方针,报告了一例与CASPR2抗体相关的单独神经病痛.
数据的提取和分析集中在患者的人口统计学,疼痛特征,神经学发现和治疗结果上.

主要成果:

一项系统性审查发现216名患者患有CASPR2抗体疾病和神经性疼痛;只有7. 4%的患者出现了孤立的疼痛.
常见的疼痛表型包括严重的远端灼热疼痛 (50.3%),广泛的肌痛/疼痛 (21.1%),以及严重的背部疼痛 (8.8%).
免疫治疗,特别是二线治疗,显著改善疼痛 (85. 4%) 和缓解 (38. 2%),而症状治疗效果较差 (55. 1% 的改善, 20. 4% 的缓解).

结论:

神经性疼痛是CASPR2抗体疾病的显著和潜在的孤立症状.
鉴于免疫治疗的有效性,建议对神经性疼痛患者进行CASPR2抗体检测.
及时启动和升级免疫疗法可以使这些患者获得良好的结果.

关键词:

CASPR2 抗体免疫疗法神经性疼痛利图西马布

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