在患有心血管风险因素的患者中,甘油三和HDL比率与亚临床心肌损伤的可能相关性
Velia Cassano1, Graziella D'Arrigo2, Mercedes Gori3
1Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.
Diabetes research and clinical practice
|August 30, 2025
概括
甘油三与高密度脂蛋白胆固醇 (TG/ HDL- C) 的比率是早期心血管疾病风险的简单标记. 患者TG/ HDL- C比率升高表明心肌功能障碍,即使没有症状.
科学领域:
- 心脏病学
- 代谢综合征
- 生物标志物
背景情况:
- 甘油三与高密度脂蛋白胆固醇 (TG/HDL-C) 的比例被认为是心血管疾病的预测指标.
- 亚临床心肌损伤是心血管风险的早期指标.
研究的目的:
- 评估TG/HDL-C比率作为心血管风险因素.
- 研究TG/HDL-C比率与亚临床心肌损伤之间的相关性.
主要方法:
- 545名患者接受了口服葡萄糖耐受性测试 (OGTT).
- 使用甘油三和甘油三胆固醇度计算TG/ HDL- C比率.
- 患者根据TG/ HDL- C值分为四分之一.
主要成果:
- 在TG/ HDL- C四分位数中观察到葡萄糖代谢和胰岛素敏感性的逐渐恶化.
- 左心室全球纵向应变 (GLS) 是缩水功能的测量,在四分位数中逐渐恶化.
- 在TG/ HDL- C比率上升1个单位与病态GLS的可能性增加61%.
结论:
- 高的TG/ HDL- C比率与临床下心肌功能障碍有关,独立于临床症状.
- TG/HDL-C比为早期心血管风险识别提供了简单而有价值的标记.
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