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Updated: Sep 9, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

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通过从复合形成中脱β-arrestin信号传递来改变大麻素偏差的A2A-CB2受体异构体功能

Rafael Rivas-Santisteban1, Carlos Ferreiro-Vera2, Verónica Sánchez de Medina2

  • 1Molecular Neurobiology Laboratory, Dept. Biochemistry and Molecular Biomedicine, Universitat de Barcelona, Barcelona, Spain; CiberNed, Network Center for Biomedical Research in Neurodegenerative Diseases, Spanish National Health Institute, Madrid. Spain.

Biochemical pharmacology
|August 30, 2025
PubMed
概括

大麻二醇 (CBD) 作为氨酸A2A-大麻素CB2受体异构体的一种偏向性基调节剂. 它选择性地改变信号通路而不影响复杂的形成,揭示了CBD作用的新机制.

关键词:
有偏差的信号功能选择性GPCR异构体在NanoBRET植物大麻素β-阿雷斯

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