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Updated: May 6, 2026

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基于基的新型光固化根管堵塞材料的生物相容性:体外和体外分析

Moe Sandar Kyaw¹, Yoshio Yahata², Masato Nakano¹

¹Division of Operative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Journal of endodontics

|August 30, 2025

概括

在小鼠研究中,OdneFill是一种新的根管材料,具有极佳的生物相容性和最小的炎症. 这是一种更安全的替代品,

科学领域:

生物材料科学
牙科材料
恢复性牙科

背景情况:

评估新型牙科材料的生物相容性对于患者安全和治疗成功至关重要.
这是一种新的光可固化的水凝基根通道堵塞材料.
在体内和体外分析对于全面的生物相容性评估至关重要.

研究的目的:

评估OdneFill的生物相容性,这是一种新型的光可固化水凝根管堵塞材料.
为了比较OdneFill对Gutta Percha与AH Plus密封剂的生物反应.
评估材料的炎症和细胞毒性作用.

主要方法:

在小鼠下第一个牙的体内研究中,只有仪器组,OdneFill,Gutta Percha + AH Plus和健康的牙.
微计算机断层扫描,组织学分析,以及在3,28和90天内进行免疫组织结合测定.
使用RAW 264.7细胞进行细胞毒性和促炎细胞因子表达的体外评估.

主要成果:

两组之间没有观察到骨质再吸收的显著差异.
与单独使用仪器相比,AH Plus的炎症评分更高,中性粒细胞/巨细胞透率增加.
OdneFill的结果与仅使用仪器的组相似,对细胞活力或炎症性细胞因子表达没有不良影响.

结论:

与Gutta Percha与AH Plus相比,OdneFill具有更高的生物相容性.
这使得它成为根管堵塞的有希望的材料.
这些发现支持OdneFill作为内脏病的安全有效替代品.

关键词:

所有在一个封闭生物相容性水凝免疫细胞炎症发生

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