预计患有严重急性胰腺炎的阿尔伯明输液的影响:随机对照试验
Wenqing Shu1, Jianhua Wan1, Huiting Xu2
1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
概括
在严重的急性胰腺炎患者中,使用白蛋白并没有改善系统性炎症反应综合征 (SIRS) 缓解或生存率. 然而,它确实显示了在这种重症监护环境中败血症发病率下降的趋势.
科学领域:
- 危急护理医学
- 胃肠病学
- 临床试验
背景情况:
- 之前的研究表明,在重症患者中使用白蛋白有益.
- 胺在严重急性胰腺炎中的作用尚未研究.
研究的目的:
- 评估在严重急性胰腺炎患者中的白蛋白疗效.
- 评估其对全身炎症反应综合征 (SIRS) 和死亡率的影响.
主要方法:
- 一个单中心随机试验,涉及60名急性胰腺炎的ICU患者.
- 5%白蛋白加结晶体与单独结晶体的比较.
- 主要终点:SIRS在第3天缓解;副主要终点:60天死亡率.
主要成果:
- 两组之间SIRS缓解或60天死亡率没有显著差异.
- 在白蛋白组观察到较低的败血症发病率 (10%对比36. 7%,P=0. 01).
- 没有显著的差异患者的特征或液体的管理.
结论:
- 在急性胰腺炎中,使用白蛋白并没有显著改善SIRS缓解或死亡率.
- 降低败血症发病率的潜在好处需要进一步调查.
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