与代谢功能障碍相关的脂肪性肝病和心房的纵向进展:一项前性研究
Yali Niu1, Tianrun Wang2, Xiaocan Jia1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 30, 2025
概括
与代谢功能失调相关的脂肪性肝病 (MASLD) 增加了心房 (AF) 进展的风险. 冠状动脉内膜厚度 (cIMT) 显著调节这种关联,突出显示MASLD患者需要动脉样硬化监测.
科学领域:
- 心脏病学
- 肝病学
- 代谢疾病
背景情况:
- 心房动 (AF) 经常与心血管并发症如心肌梗塞和中风并存.
- 与代谢功能失调相关的脂肪性肝病 (MASLD) 是FA发展和死亡的一个不充分认识的因素.
- 动脉内膜厚度 (cIMT) 是动脉样硬化的标志物,可能介导MASLD和AF之间的联系.
研究的目的:
- 研究MASLD对AF纵向进展的影响.
- 确定cIMT在MASLD和AF进展,并发症和死亡率之间的中介作用.
主要方法:
- 在350,745名参与者的多州分析中,平均时间为13.67年.
- 反事实调解分析以量化cIMT的调解效果.
- 检查了从健康到AF的转变,与AF相关的并发症和死亡.
主要成果:
- 与非MASLD患者相比,MASLD患者从健康转变为AF的风险高1.5倍.
- 在MASLD和AF之间的关联中,cIMT为16. 51%,AF并发症为18. 06%,死亡率为15. 14%.
- 观察到MASLD与AF进展,随后的并发症和整体死亡率有显著的关联.
结论:
- MASLD显著增加了纵向AF的风险.
- 在MASLD-AF关系中,cIMT是关键的调解者.
- 管理MASLD和监测动脉样硬化对于预防AF进展至关重要.
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