在婴儿期形成肠道抗体的时间动态和微生物相互作用
Ioanna Chatzigiannidou1, Pi L Johansen1, Rasmus K Dehli1
1Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
Nature communications
|August 30, 2025
概括
婴儿肠道抗生素耐药性基因 (ARG) 在6个月时达到峰值. 促进像双胞胎细菌这样的有益细菌可能会减少ARG,在生命早期提供对抗抗微生物耐药性的策略.
科学领域:
- 微生物学
- 基因组学
- 儿童医学
背景情况:
- 肠道耐药性对抗菌素耐药性 (AMR) 的传播起着至关重要的作用.
- 减少婴儿肠道微生物群抗生素耐药性基因 (ARG) 的策略尚未得到充分研究.
- 早期生命是肠道微生物群发育和AMR建立的关键窗口.
研究的目的:
- 在早期发育过程中研究婴儿肠道微生物群中的ARG动态.
- 确定影响婴儿ARG数量和组成的因素.
- 探索早期抑制抗菌素耐药性的潜在干预措施.
主要方法:
- 婴儿肠道微生物群的纵向定量基因组分析.
- 随着时间的推移跟踪ARG的丰富性和丰富性.
- 细菌分类,ARG和代谢物之间的相关性分析.
主要成果:
- 在婴儿的肠道微生物群中检测出ARG从生命的第一个星期开始,达到6个月的峰值.
- 婴儿分娩方式影响早期的ARG动态,阴道分娩与更高的ARG含量有关.
- 母亲传播大肠杆菌菌株有助于婴儿的ARG负载.
- 芳香乳酸产生双倍细菌与大肠杆菌等ARG丰富的细菌相反相关.
- 芳香乳酸抑制了大肠杆菌和其他富含ARG的机会性细菌的体外生长.
结论:
- 时间微生物相互作用显著塑造了婴儿的肠道抵抗性.
- 促进芳香乳酸产生双胞胎菌的殖民是一种潜在的干预策略,以减少婴儿早期的ARG.
- 针对生命早期的微生物发展可以帮助制抗菌素耐药性的传播.
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