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PYM1以基因架构依赖的方式限制非正规的外结复合体占用,以调整mRNA表达

Manu Sanjeev1,2, Lauren A Woodward1, Michael L Schiff3

  • 1Department of Molecular Genetics, The Ohio State University, Columbus, OH, 43210, USA.

Nature communications
|August 30, 2025
PubMed
概括

埃克森结合复合体 (EJC) 拆解因子PYM1使EJC独立于翻译而变得不稳定. PYM1 限制非正规的 EJC,这是一个由黄病毒劫持的功能,以改变宿主 mRNA 的调节.

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