与健康受试者的基于努力的决策和冷漠相关的前驱运动回路
Gerard Derosiere1,2, Pierre Vassiliadis3, Laurence Dricot4
1Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium. gerard.derosiere@inserm.fr.
Communications biology
|August 30, 2025
概括
这项研究揭示了大脑电路连接如何影响努力和无动于衷的决策. 这些发现突出了与冷漠和动机行为相关的特定途径, 建议新的治疗目标.
科学领域:
- 神经科学
- 认知神经科学
- 神经学
背景情况:
- 无动于衷包括基于努力的决策能力受损,以及前基底 (BG) 电路的改变.
- 之前关于冷漠和决策的研究还没有完全探索前端-BG-M1电路连接.
研究的目的:
- 调查前端-M1,前端-BG-M1和M1内部电路的结构和有效连接性.
- 检查大脑电路测量与努力和奖励估值的计算参数之间的联系.
主要方法:
- 在45名健康参与者中使用了通道图和配对脉冲跨磁刺激.
- 与冷漠度评分和决策行为计算模型相关的连接度.
主要成果:
- 无动于衷的得分与轨道前皮层电路的结构和有效连接相关.
- 与补充运动区域电路相关的努力估值;与M1内GABAergic电路相关的奖励估值.
结论:
- 可分离的电路级贡献是动机行为的不同方面.
- 确定了治疗冷漠的潜在神经调节点.
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