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Updated: Sep 9, 2025

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
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Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

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通过SynGAP的不稳定,Necdin的损失会导致社会缺陷和异常的突触功能

Xiangyu Li1,2,3,4,5, Ibrahim Bader1,2, Xin Li1,2,3,4,5

  • 1Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.

Molecular psychiatry
|August 30, 2025
PubMed
概括

Necdin 调节 SynGAP 蛋白质水平,影响大脑发育和社会行为. 在Necdin缺乏的小鼠中恢复SynGAP可挽救自闭症类症状和突触异常.

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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