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Updated: Apr 13, 2026

A Multi-detection Assay for Malaria Transmitting Mosquitoes

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使用基于DNA的"SNAILS"生物传感器检测日虫

Alexander J Webb¹, Qin-Ping Zhao², Fiona Allan^3,4

¹Section of Structural and Synthetic Biology, Department of Infectious Disease, Imperial College London, London, UK.

Communications biology

|August 30, 2025

概括

一个新的DNA生物传感器,

科学领域:

寄生虫学
分子诊断
被忽视的热带疾病

背景情况:

这种疾病是全球严重的健康问题,特别是在低收入和中等收入国家,
japonicum 菌会引起肠道菌病并感染许多哺乳动物,因此需要专门的诊断工具.

研究的目的:

改进基于DNA的"SNAILS"生物传感器技术以检测瘤.
通过开发的生物传感器, 专门检测日本虫.

主要方法:

开发和优化四个"SNAILS"探测器对.
生物传感器用于检测S. japonicum和Schistosoma mansoni的基因组DNA.

主要成果:

一对优化的"SNAILS"探测器成功检测到了S. japonicum.
生物传感器区分了S. japonicum和S. mansoni的基因组DNA.

结论:

精致的"SNAILS"DNA生物传感器显示出对特定的S. japonicum检测有希望.
这项技术可以帮助控制杆菌病的传播.

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Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Published on: May 22, 2018

Detection of Plasmodium Sporozoites in Anopheles Mosquitoes using an Enzyme-linked Immunosorbent Assay

Detection of Plasmodium Sporozoites in Anopheles Mosquitoes using an Enzyme-linked Immunosorbent Assay

Published on: September 30, 2021

相关概念视频

Southern Blot

Southern Blot

Agarose gel electrophoresis is very useful in separating DNA fragments by size. Running a DNA ladder containing fragments of the known length alongside the sample helps determine the approximate length of the sample DNA fragments. However, additional steps are needed to verify the sequence identity of the sample DNA fragments.
Denatured DNA fragments must be transferred onto a carrier membrane from the gel to make it accessible to a probe - a small ssDNA fragment complementary to the target DNA...