探索糖尿病临床试验参与:多元化的小组采访研究
Deborah A Taira1,2, Kauilaonālani Tengan3, Julia Takata3
1The Queen's Medical Center, Honolulu, HI, USA. dtjuarez@hawaii.edu.
Therapeutic innovation & regulatory science
|August 30, 2025
概括
通过强调社区利益和使用值得信赖的当地医生来提高临床试验的多样性. 患者的交流偏好因种族而异,
科学领域:
- 健康上的差异
- 临床试验招聘
- 医疗公平
背景情况:
- 原住民夏威夷人 (NH),太平洋岛民 (PI) 和菲律宾人患2型糖尿病的比例很高,但在临床试验中代表性不足.
- 确保在临床试验中的多元参与对于所有人群的治疗安全性和有效性至关重要.
- 了解代表性不足的群体的动机和障碍是改善试验包容性的关键.
研究的目的:
- 探索参与临床试验的动机,障碍和沟通偏好.
- 专注于多元化的住院患者,特别是代表性不足的种族/民族群体.
- 为公平的临床试验招生提供信息.
主要方法:
- 面对56名夏威夷住院患者进行的半结构面试.
- 参与者对参与试验的原因进行了排名,并回答了开放式问题.
- 量化数据是描述性的;定性数据是按种族/民族进行快速定性分析的.
主要成果:
- 84%的参与者愿意参加试验,但大多数人从未被邀请过.
- 动机不同:NH优先考虑社区/治疗机会,PI关注医生/科学,菲律宾人关注治疗/科学,白人参与者关注激励/社区.
- 障碍包括对药物风险的担忧,缺乏理解和不信任, 家庭福利是NH和PI的主要动机.
- 最喜欢的沟通方式:医生推,短信和实体邮件.
结论:
- 文化定制的招聘强调家庭和社区的好处是必不可少的.
- 让当地值得信赖的医疗服务提供者参与可以提高参与度.
- 利用与文化相关的沟通策略可以改善2型糖尿病患者中代表性不足的人群的临床试验入学率.
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