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Updated: Sep 9, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Published on: February 20, 2018

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通过新设计的激应剂调整G-CSFR信号

Timo Ullrich1, Christoph Pollmann2, Malte Ritter3

  • 1Max Planck Institute for Biology, Department Protein Evolution, 72076 Tübingen, Germany; Friedrich Miescher Laboratory of the Max Planck Society, 72076 Tübingen, Germany.

Molecular therapy : the journal of the American Society of Gene Therapy
|August 31, 2025
PubMed
概括

针对颗粒细胞殖民地刺激因子受体 (G-CSFR) 设计的激动剂可以选择性地促进造血干细胞的分化而不是增殖. 这些新型细胞因子为向药物发现提供了增强的稳定性和治疗潜力.

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