血基生物标志物的表现对于人类心脏起器阶段:训练与特征选择方法一样重要
Carla S Möller-Levet1, Simon N Archer2, Derk-Jan Dijk2,3
1Bioinformatics Core Facility, Faculty of Health & Medical Sciences, University of Surrey, Guildford, UK.
Journal of biological rhythms
|August 31, 2025
概括
开发可靠的昼夜生物标志物需要仔细考虑训练数据和实验条件. 目前的方法显示了变化性,并且可能不适用于轮班工作等现实场景.
科学领域:
- 时间生物学
- 分子生物学
- 生物标志物发现
背景情况:
- 循环医学利用生物标志物来评估人类的健康.
- 低负荷,多变量分子方法对现实世界昼夜阶段评估具有前景.
- 缺乏确定的标准阻碍了昼夜生物标志物的开发和评估.
研究的目的:
- 在开发血基生物标志物上神核 (SCN) 阶段中探索决定因素和混因素.
- 为了比较特征选择方法 (部分最小平方回归,ZeitZeiger,弹性网) 和时钟基因.
- 调查培训样本大小和实验方案对生物标志物性能的影响.
主要方法:
- 重新分析公开可用的数据集.
- 三种特征选择方法和标准时钟基因组的比较.
- 探索训练样本大小和实验方案的影响.
主要成果:
- 训练样本的小规模导致过度适配和表现不佳.
- 生物标志物的性能取决于特征选择方法和训练数据的实验条件.
- 在基线条件下训练的生物标志物可能在现实场景中表现不佳 (例如,轮班工作).
- 选择的分子特征几乎没有重叠,但与类固醇激素反应 (如皮质醇) 有关.
结论:
- 昼夜生物标记的开发必须遵循既定的生物标记概念和昼夜生物学的原则.
- 目前的方法在一般化方面存在局限性,特别是在现实应用中.
- 需要进一步的研究来建立生日生物标志物开发和验证的强有力的标准.
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