早期的肠道微生物成熟度调节了血脑屏障和认知发展
Zachary M Zemmel1,2, Xiaobing Fan3, Yueyue Yu4,5
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Gut microbes
|August 31, 2025
概括
早期肠道微生物组组成显著影响大脑发育和血脑屏障 (BBB) 的完整性. 一个完整的微生物组增强认知功能和BBB强度, 不像一个早产的微生物组.
科学领域:
- 神经生物学
- 微生物学
- 发育生物学
背景情况:
- 人们越来越认识到肠道微生物在神经生物学和疾病中的作用.
- 血脑屏障 (BBB) 的完整性对大脑功能至关重要,但其早期发育和微生物群的影响尚不清楚.
研究的目的:
- 研究早期肠道微生物群殖民对小鼠BBB发育和认知功能的影响.
- 阐明将微生物成熟与BBB完整性和神经发育联系在一起的分子机制.
主要方法:
- 没有细菌的小鼠与人类的完整或早产婴儿肠道微生物群结合.
- 评估记忆和学习能力.
- 在生命早期测量BBB透性.
- 全脑单细胞RNA测序的BBB细胞类型.
- 基因组学和代谢学分析
主要成果:
- 与早产微生物组相比,具有完整生长微生物组的小鼠表现出增强的记忆力,学习能力和降低的BBB透性.
- 与早产相关的微生物组导致BBB细胞的突触信号基因下调.
- 特定的细菌群体和代谢途径 (降低的甲和甲) 与长期的微生物群有关.
结论:
- 微生物组的成熟度对认知发展至关重要的BBB转录程序产生重大影响.
- 肠道微生物组通过调节生命早期的BBB完整性来增强神经发育结果的潜在治疗目标.
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