美国50岁及以上成年人RSV检测模式和特征
David Singer1, Emily K Horn2, Yan Wang3
1GSK, FMC Tower, Suite 1700, 2929 Walnut Street, Philadelphia, PA, 19104, USA.
Infectious diseases and therapy
|August 31, 2025
概括
在美国50岁以上的成年人中,尽管发病率上升,但呼吸道同胞细胞病毒 (RSV) 检测仍然很少. 检测可能性因护理环境和医疗机构而异,突出显示RSV病例的不足.
科学领域:
- 流行病学
- 公共卫生
- 传染性疾病
背景情况:
- 呼吸道同胞病毒 (RSV) 是50岁及以上成年人急性呼吸道疾病 (ARI) 的重要原因.
- 由于测试和测试灵敏度有限,RSV的诊断不足是常见的.
- 了解检测模式对于评估RSV流行病学和疾病负担至关重要.
研究的目的:
- 调查美国50岁以上患有肺炎的成年人呼吸道病毒检测模式.
- 在这个人口群体中确定与RSV测试相关的特征.
主要方法:
- 电子健康记录的回顾性分析 (2015-2023年) 对50岁以上的成年人进行医疗照顾的ARI.
- 根据流行病学年和护理环境分层计算RSV和其他呼吸道病毒检测的百分比.
- 多变量逻辑回归以评估与RSV检测概率相关的因素.
主要成果:
- 在超过2200万例的ARI中,只有2. 4%进行RSV检测.
- 随着时间的推移,RSV检测率从1.3%增加到5.9%,但仍低于流感和SARS-CoV-2检测.
- 与门诊患者相比,住院和急诊部门的RSV检测率更高.
- 密切护理环境 (住院,ED) 和医疗保健组织与RSV检测的可能性增加有显著的关联.
结论:
- 根据护理环境和医疗机构的强度,RSV检测的频率有很大差异.
- 尽管出现上升趋势,但在50岁以上的美国成年人中,RSV检测仍不常见.
- 在评估疾病负担和预防策略时,必须考虑RSV病例的不足.
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