在妊娠前后的动脉样硬化:系统性审查和元分析
概括
患有妊娠前的女性患有动脉样硬化的患病率较高,比未出现并发症的女性早大约10年. 早期心血管风险管理对这一群体至关重要.
科学领域:
- 心血管健康
- 妇产科
- 流行病学
背景情况:
- 妊娠前影响高达8%的孕妇.
- 它与缺血性心脏病和脑血管疾病的风险增加有关.
- 早期发现心血管风险是预防的关键.
研究的目的:
- 确定怀孕后女性临床和亚临床动脉样硬化的患病率.
- 为了比较患有先兆子的女性和没有先兆子的女性之间的动脉样硬化率.
- 分析母亲年龄增长对这些比例的影响.
主要方法:
- 一项对11项研究 (13,217名参与者) 的系统文献综述和元分析.
- 包括通过超声波或CT扫描记录系统性动脉样硬化的研究.
- 随机效应元分析计算的几率比率 (OR) 使用95%的置信区间 (CI).
主要成果:
- 血动脉样硬化前症的综合OR为1. 57 (95% CI,1. 39-1. 78).
- 动脉样硬化风险随着母亲的年龄增加而增加,在40至49岁 (OR,1. 59) 和50至60岁 (OR,2. 00) 的年龄组显著增加.
- 曾经患有黄昏前症的女性的患病率与未患有黄昏前症的女性相似,年龄比她们大10岁.
结论:
- 患有妊娠前的女性更常出现动脉样硬化,大约10年前出现.
- 需要有针对性的初级预防策略.
- 这旨在减少心血管疾病的发病率和死亡率.
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