发展性语言障碍儿童的功能网络连接性改变的初步证据
Gaelle E Doucet1, Jordanna A Kruse2, Nichole M Eden3
1Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United States; Center for Pediatric Brain Health, Boys Town National Research Hospital, Omaha, NE, United States; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States.
患有发育性语言障碍 (DLD) 的儿童在感觉运动,认知和默认模式网络中表现出广泛的下脑连接. 这些广泛的脑功能异常可能解释了DLD的其他认知和运动障碍.
科学领域:
- 神经科学
- 发展心理学
- 认知科学
背景情况:
- 发育性语言障碍 (DLD) 是一种影响语言,执行和运动功能的常见神经发育状况.
- 以前对DLD脑部异常的研究主要集中在使用功能性MRI (fMRI) 的语言网络上.
- 了解DLD的更广泛的神经基础对于解释相关的非语言缺陷至关重要.
研究的目的:
- 使用休息状态的fMRI检查DLD儿童的全脑功能连接 (FC).
- 与典型发育 (TD) 儿童相比,确定在DLD中表现出改变的特定大脑网络.
- 探讨大脑功能异常的广泛存在与 DLD 的更广泛的认知/运动障碍之间的关系.
主要方法:
- 使用休息状态的fMRI来评估全脑功能连接 (FC).
- 这项研究包括22名患有DLD的儿童和23名年龄在7至13岁之间的TD儿童.
- 在FC分析中采用非参数网络统计方法.
主要成果:
- 与TD儿童相比,DLD儿童的全脑FC显著降低.
- 主要在感觉运动 (SM),认知控制 (CC) 和默认模式 (DM) 网络中观察到改变的FC.
- 具体的修改包括在DM网络和SM-DM和SM-CC网络之间降低FC.
结论:
- 这项研究揭示了DLD儿童的广泛,广泛的功能性脑部异常,
- 这些发现突出了支持感觉运动,认知和默认模式功能的网络连接的改变.
- 这些广泛的功能缺陷为与DLD相关的各种认知和运动障碍提供了潜在的神经生物学解释.
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