饮食中摄入维生素E与代谢功能障碍相关的脂肪性肝病患者的死亡率较低有关
Yajie Peng1, Wanhong Wu2, Lin Chen3
1Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Nutrition research (New York, N.Y.)
|August 31, 2025
概括
较高的饮食维生素E摄入量与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的死亡率降低有关. 这表明维生素E可能是MASLD患者有益的饮食干预措施.
科学领域:
- 肝病学
- 营养科学
- 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 饮食改变对于管理MASLD至关重要.
- 饮食中维生素E对MASLD患者死亡率的具体影响需要进一步阐明.
研究的目的:
- 在被诊断患有MASLD的患者中研究饮食中摄入维生素E与死亡风险之间的关联.
- 确定增加维生素E的摄入是否与该群体的生存结果有相关性.
主要方法:
- 利用国家健康和营养检查调查 (NHANES) (1999-2018) 和国家死亡指数 (NDI) 的数据.
- 包括7883名MASLD患者,使用标准化USDA方法评估饮食维生素E摄入量.
- 采用卡普兰-梅尔曲线和考克斯回归模型, 并根据多个混因素进行调整.
主要成果:
- 饮食中摄入较多的维生素E与全因死亡风险的显著降低有关.
- 在MASLD患者中,增加维生素E的摄入与心血管疾病 (CVD) 死亡率的降低相关.
- 在非久坐的人群和总胆红素或纤维性肝脏增加的人群中,保护作用更为明显.
结论:
- 饮食中的维生素E摄入量与MASLD患者的死亡率有显著的反向关系.
- 增加饮食维生素E可能是改善MASLD结果的有希望的预防策略.
- 需要进一步研究维生素E作为MASLD的治疗干预措施.
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