在计算病理学中检测分布外数据的稳定距离
Di Zhang1, Jiusong Ge1, Jiashuai Liu1
1School of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China; Shaanxi Provincial Key Laboratory of Big Data Knowledge Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
Medical image analysis
|August 31, 2025
概括
计算病理模型需要分布外 (OOD) 检测以获得可靠的临床使用. 我们推出了稳定距离 (StaDis) 一种用于计算病理学的新的插入式OOD方法, 在新的基准上取得了最先进的结果.
科学领域:
- 计算病理学
- 医学中的人工智能
- 医学图像分析
背景情况:
- 计算病理学 (CPath) 模型提高了病理学家的效率,但风险是无法看到数据的不可靠性.
- 在CPath模型中缺乏OOD检测阻碍了临床信任和安全性.
- 现有的OOD方法并不适合计算病理学的独特挑战.
研究的目的:
- 引入专门为计算病理学设计的新型OOD检测方法.
- 开发一种在现实临床环境中确保CPath模型可靠性的方法.
- 建立新的基准来评估病理数据中的OOD检测.
主要方法:
- 拟议的稳定距离 (StaDis) 是一个插即用OOD检测模块,用于测量图像与其扰乱版本之间的差异.
- 在使用多个实例学习 (MIL) 框架的整个幻灯片图像 (WSI) 层面探索OOD检测.
- 开发了异常检测,罕见病例挖掘和冷部分识别的病理性OOD检测基准.
主要成果:
- 在38个实验中,StaDis在23个实验中实现了最先进的性能,并在10个实验中排名第二.
- 通过使用"Conch"骨干的StaDis进行基于补丁的异常检测,AUROC提高了7.91%.
- 这种方法在各种病理性OOD检测场景中被证明有效.
结论:
- 稳定距离 (StaDis) 为计算病理学中OOD检测提供了强大而可适应的解决方案.
- 拟议的方法提高了临床部署CPath模型的可靠性和可信性.
- 开发的基准有助于在病理学中对OOD检测技术的未来研究和验证.
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