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相关概念视频

Tissues01:18

Tissues

80.7K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
80.7K
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

5.9K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
5.9K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Three-Compartment Open Model01:06

Three-Compartment Open Model

421
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
421
Dense Connective Tissue01:13

Dense Connective Tissue

8.6K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
8.6K
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

14.7K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
14.7K

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相关实验视频

Updated: Sep 9, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
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Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

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一种具有中等细胞密度的组织连续模型

Yashar Ebadi1, Elizabeth D Shih2, Victor H Barocas2

  • 1Department of Mechanical Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.

Computers in biology and medicine
|August 31, 2025
PubMed
概括
此摘要是机器生成的。

一个新的混合模型准确地预测不同密度的组织中的细胞压力. 这有助于我们更好地理解脑动脉瘤等疾病中的机械传导.

关键词:
大脑动脉瘤限制混合模型埃舍尔比溶液在FEM增长和改造混合规则血管平滑肌细胞

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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment

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相关实验视频

Last Updated: Sep 9, 2025

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Finite Element Modelling of a Cellular Electric Microenvironment

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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
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科学领域:

  • 生物医学工程
  • 细胞力学
  • 组织工程

背景情况:

  • 细胞通过机械传导对机械力做出反应,这对组织发育至关重要.
  • 现有的模型难以准确预测中等细胞密度的组织中的细胞应激.

研究的目的:

  • 开发和验证一种用于预测中等细胞密度的组织中的细胞应激的新型模型.
  • 研究细胞形状,密度和材料特性对组织压力的影响.

主要方法:

  • 使用有限元模型 (FEM) 模拟具有不同细胞形状 (球形,形,圆柱形),体积分数和刚度比的组织样本.
  • 代表体积元素 (RVE) 用于在单轴拉伸下建模组织力学.
  • 结合混合物规则 (ROM) 和Eshelby的纳入模型的混合模型被开发并与FEM结果进行验证.

主要成果:

  • 混合规则 (ROM) 模型在低细胞密度时显示出不准确性,而Eshelby的模型在高密度时显示出不准确性.
  • 与FEM相比,拟议的混合模型在广泛的细胞密度的预测中表现出更高的准确性.
  • 混合模型有效地捕捉了具有复杂非线性材料特性的组织中的应力.

结论:

  • 开发的混合模型为具有中间细胞密度的组织中模拟细胞应激提供了更准确和多用途的方法.
  • 这项工作增强了对包括脑动脉瘤在内的各种生理和病理条件中的机械传导的理解.
  • 该模型为研究组织力学和指导治疗策略提供了宝贵的工具.