在低度使用BD Barricor采血管时,最大限度地降低高灵敏度的Troponin delta变化
Albert K Y Tsui1, Jialin Qiu2, Isolde Seiden-Long3
1Department of Laboratory Medicine and Pathology, College of Health Science, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Alberta Precision Laboratories, Alberta, Canada.
Clinical biochemistry
|August 31, 2025
概括
巴里克管显著提高了低托洛的结果的可复制性. 这减少了分析前的变化,提高了加快治疗途径的诊断准确性.
科学领域:
- 临床化学
- 心血管诊断
- 实验室医学
背景情况:
- 在加速诊断途径中,准确的风险分层依赖于可重现的高灵敏度平素 (hs-cTn) 测定.
- 为了提高hs-cTnT结果的可靠性,尽量减少分析前的变化.
- 在BD Barricor采集管中显示了降低分析前变化的潜力.
研究的目的:
- 评估使用BD Barricor管与血分离管 (PST) 的hs-cTnT结果的可重复性.
- 评估采集管类型对hs-cTnT在≤20 ng/L度的变异性的影响.
主要方法:
- 九家医院对患者内hs- cTnT结果进行了回顾性分析,比较了PST (n=336) 和Barricor (n=327) 管.
- 对hs-cTnT结果的总变化计算 ≤ 20 ng/L.
- 根据欧洲心脏病学会的0/1h算法分组样本 (<3 ng/L,3-4 ng/L,≥5 ng/L).
主要成果:
- 对于hs- cTnT ≤20 ng/ L的总测试变化为PST的14. 8%,而巴里克管的8. 6%.
- 与PST (80. 4%) 相比,巴里克管的患者内复制值< 3 ng/ L的比例显著更高 (p < 0. 001).
- 在PST (41分钟) 和Barricor (45分钟) 之间,采样时间的中位数相似.
结论:
- 与PST相比,BD Barricor管在≤20 ng/L度下提供了更可重复的hs-cTnT结果.
- 使用巴里克管可显著降低连续素测量的变异性.
- 这些发现支持使用巴里克管来提高心脏诊断的准确性.
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