清晰的尿微生物组特征与肝硬化患者的尿路感染风险有关:试点研究
Johannes Woltsche1, Christian Pacher-Deutsch2, Stefan Fürst3
1Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
概括
肝硬化患者和健康的尿路微生物群 (UMB) 呈现出不同的微生物模式. 像Prevotella这样的特定细菌可以在高危人群中预防尿路感染.
科学领域:
- 微生物学
- 胃肠病学
- 尿道病学
背景情况:
- 患有肝硬化的人面临更高的尿路感染风险.
- 尿路微生物组 (UMB) 在肝硬化患者的尿路感染易感性中的作用尚不清楚.
- 这项试点研究研究了肝硬化患者和没有尿路感染的UMB.
研究的目的:
- 在肝硬化患者中描述UMB.
- 确定发生尿路感染的患者和保持无尿路感染的患者之间UMB的差异.
- 探索特定微生物在UMB中的潜在保护作用.
主要方法:
- 使用16S rRNA基因测序分析了39名患者的尿样.
- 患者被分为患有尿路感染 (dUTI) 和无尿路感染 (no_UTI) 的两组.
- 使用QIIME 2,ANCOM和LEfSe进行了微生物分析.
主要成果:
- 在dUTI和no_UTI组之间发现了UMBβ多样性的显著差异.
- 没有尿道感染的群体表现出更高的细菌群,Prevotella和Corynebacteriaceae.
- 在 dUTI 组中,
结论:
- 在肝硬化患者中,明显的UMB模式可能会对尿路感染提供保护.
- 在UMB中的Prevotella和Corynebacterium可能起着保护作用.
- 这些微生物可能是该群体中尿路感染预防策略的目标.
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