药物输送,开发和技术方面的外围药物排泄支架
Sarika A Jadhav1, Ankur J Raval2, Vandana B Patravale1
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400 019 Maharashtra, India.
Advanced drug delivery reviews
|August 31, 2025
概括
药物释放支架通过预防静脉缩改善了外周动脉疾病的治疗. 由于慢性疾病的复杂性和监管缺陷,加强体外检测对于质量控制至关重要.
科学领域:
- 生物医学工程
- 材料科学
- 药理学
背景情况:
- 药物释放支架 (DES) 是动脉封闭的标准,特别是在外周动脉疾病 (PAD) 中.
- 改进包括颗粒系统,细胞静止剂和生物降解聚合物.
- 挑战包括慢性疾病,复发性静脉缩,动物研究的可行性有限,以及FDA批准的外围DES体外试验方案的缺乏.
研究的目的:
- 为外围DES提供药物输送策略的全面审查.
- 讨论涂层方法,评估标准和体外/临床前测试.
- 突出这一领域的进步和未来的机会.
主要方法:
- 对外围DES的药物输送策略,涂层技术和评估参数的文献综述.
- 在体外释放药物的分析,透研究和临床前动物模型.
- 讨论稳定性测试,监管考虑和质量控制.
主要成果:
- 通过集成的系统和材料提高了外围DES的性能.
- 作为质量控制策略,建议进行加速体外释放测试.
- 稳定性测试的标准监管准则是有限的.
结论:
- 对于外围DES质量控制,需要修改策略和加速体外测试.
- 综合评估包括涂层均性,药物含量,生物降解性和无菌性.
- 进一步的研究和标准化框架对于推进外围DES技术至关重要.
相关概念视频
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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01:22Drug Delivery: Miscellaneous Routes
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
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01:18Drug Delivery: Enteral Route
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01:29Drug Delivery: Parenteral Route
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01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
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