直接纸封装材料的临床成功比较:随机临床试验的网络元回归
Ömer Hatipoğlu1, Elif Varlı Tekingür1, Fatma Pertek Hatipoğlu2
1Department of Restorative Dentistry, Recep Tayyip Erdoğan University, Turkey.
Journal of dentistry
|August 31, 2025
概括
在永久牙中,生物和MTA的临床成功率高于氧化物. 然而,证据的局限性意味着没有任何材料是绝对优越的生命脉治疗.
科学领域:
- 牙科学
- 牙科材料科学
- 恢复性内脏牙科
背景情况:
- 直接皮质封闭 (DPC) 是一种重要的皮质疗法,旨在保持皮质活力.
- 选择最佳的DPC材料对于成功的治疗结果至关重要.
- 目前对DPC材料进行比较的证据在随访持续时间和异质性方面存在局限性.
研究的目的:
- 系统地审查和比较各种直接纸封盖材料的临床有效性.
- 将随访持续时间作为网络元回归 (NMR) 的共变量.
- 评估不同DPC材料在永久牙中的相对成功率.
主要方法:
- 在主要数据库 (PubMed,Cochrane,Scopus,Web of Science) 进行了全面的文献搜索.
- 包括至少两项DPC材料和至少3个月的随机临床试验.
- 贝叶斯核磁共振分析整合了直接和间接证据,计算了概率比率 (OR) 和可信区间 (CrI),并根据随访时间进行了调整.
主要成果:
- 在NMR中包括了19项随机对照试验 (1733名患者,6个DPC材料).
- 生物 (OR:4. 41) 和MTA (OR:3. 02) 的临床成功率明显高于氧化.
- 在SUCRA的成功概率中,生物和MTA排名最高,而氧化排名最低.
结论:
- 与氧化物相比,生物和MTA在成熟的永久牙中具有更高的临床成功率.
- 这些基于酸盐的材料可能在肝脏治疗中提供更可预测的结果.
- 尽管结果很有希望,但大量的异质性和证据的低确定性需要谨慎的解释;恢复性完整性也是长期成功的关键.
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