孕妇脂肪和炎症:孕妇缺铁的危险因素
Sabrina P Demirdjian1, Maria S Mulhern1, Maeve A Kerr1
1Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland.
孕妇的肥胖和炎症增加了怀孕后期缺铁的风险. 妊娠早期的可溶性转移素受体 (sTfR) 有效预测这种风险,特别是在超重或肥胖的个体中.
科学领域:
- 产科和妇科
- 营养科学
- 产妇和胎儿医学
背景情况:
- 在怀孕期间,肥胖和缺铁是全球重要的健康问题,对母亲和婴儿构成风险.
- 肥胖引起的炎症与怀孕妇女发病或贫血之间的关系尚不清楚.
研究的目的:
- 调查孕妇肥胖,炎症和妊娠期间铁的状况之间的联系.
- 确定孕产妇的脂肪是否影响怀孕早期铁标志物的预测准确性.
主要方法:
- 一个随机对照试验的二次分析,涉及接受铁增强型多维生素的单独怀孕.
- 在多个妊娠周 (GW) 评估体质指数 (BMI),体质组成,铁标志物和血红蛋白水平.
- 使用促炎细胞因子计算炎症评分,以将参与者分为高或低炎症.
主要成果:
- 体重指数和脂肪质量指数在12GW时较高,与36GW时较低的费里丁水平和更高的可溶性转移林受体 (sTfR) 水平有关.
- 与正常体重的女性相比,肥胖女性在12GW和28GW时表现出较低的转激素和度.
- 在36GW时,肥胖和炎症得分较高的孕妇的费里水平显著降低.
- 怀孕早期的sTfR (12GW) 是36GW的最强的预测因子,特别是在超重和肥胖妇女中.
结论:
- 可能由炎症引起的母体脂肪率升高,可显著增加妊娠第三季度缺铁的风险.
- 在怀孕早期测量的可溶性转移林受体 (sTfR) 是怀孕晚期缺铁的可靠预测指标.
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