在诊断为静脉血栓塞栓症的患者中发生心血管事件的风险
Frida Lonnberg1, Anwar J Siddiqui1
1Department of Medicine, Karolinska Institute, Solna; Acute and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.
The American journal of medicine
|August 31, 2025
概括
静脉血栓栓塞 (VTE) 不会增加动脉心血管事件 (ACVE) 的风险. 然而,深静脉血栓塞 (DVT) 和肺栓塞 (PE) 都与明显更高的全因死亡率有关.
科学领域:
- 心脏病学
- 血管医学
- 流行病学
背景情况:
- 心血管疾病 (CVD) 是全球的主要健康问题.
- 静脉血栓塞栓症 (VTE) 和随后的动脉心血管事件 (ACVE) 之间的关系需要进一步调查.
- 了解这种联系对于患者风险分层和管理至关重要.
研究的目的:
- 在诊断为静脉血栓塞栓症 (VTE) 的患者中调查未来动脉心血管事件 (ACVE) 的风险.
- 将深静脉血栓 (DVT) 或肺栓塞 (PE) 患者的ACVE发病率与对照组进行比较.
- 评估VTE对所有死因的影响.
主要方法:
- 斯德哥尔摩急诊室 (ED) 的成年患者的回顾性队列研究 (2016-2017).
- 包括诊断为DVT或PE的患者,不包括之前患有ACVE的患者.
- 用于估计ACVE和死亡率的调整危险比率的细灰分区危险模型,ACVE的平均随访时间为1.2年,死亡率为2.1年.
主要成果:
- 这项研究包括308,779名患者;3610人患有DVT,2358人患有PE.
- 在完整的随访中,对DVT患者的调整HR为0. 74 (95% CI,0. 59- 0. 94);对于PE患者,HR为0. 86 (95% CI,0. 67- 1. 12).
- 与对照组相比,DVT (HR 1.64) 和PE (HR 2.37) 的全因死亡率显著增加.
结论:
- 静脉血栓塞栓症 (VTE) 与随后的动脉心血管事件 (ACVE) 的风险增加无关.
- 深静脉血栓 (DVT) 和肺栓塞 (PE) 都与全因死亡率的增加显著相关.
- 这些发现突显了除了直接的血栓形成风险之外,对静脉瘤的治疗的重要性.
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