辐射召回皮肤炎 在服用Capivasertib后
Yuhao Shi1, Ian W Tattersall2, Boris Kobrinsky3
1Department of Radiation Oncology, New York University Grossman School of Medicine, New York, New York.
Practical radiation oncology
|August 31, 2025
概括
在接受PI3K/ Akt通路抑制剂治疗的患者中发生了辐射回忆性皮肤炎. 这种罕见的不良反应强调了在接受过放射治疗的患者使用capivasertib时需要谨慎.
科学领域:
- 癌症学
- 药理学
背景情况:
- 辐射回忆性皮肤炎是一种罕见的不良反应.
- 卡皮瓦塞蒂布是一种PI3K/ Akt通路抑制剂,已被批准用于治疗乳腺癌.
- 它与缓解辐射的安全性是未知的.
研究的目的:
- 报告一个辐射回忆皮肤炎的病例.
- 讨论之前接受过辐射治疗的患者对 capivasertib 的安全性.
主要方法:
- 一个患有转移性乳腺癌的病例报告.
- 患者在先前对下肢进行辐射后接受了capivasertib.
主要成果:
- 患者出现了辐射回忆性皮肤炎.
- 治疗包括皮质类固醇,抗生素和转换为alpelisib.
结论:
- 卡皮瓦塞尔提可能引发辐射回忆性皮肤炎.
- 在有放射性病史的患者使用capivasertib时应谨慎使用.
相关概念视频
Skin Cancer
4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K
Absorption of Radiation
819
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
819
Radiation: Applications
1.2K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...
1.2K
Biological Effects of Radiation
15.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.9K
Mutations
39.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
39.7K
Skin Diseases and Disorders
4.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K


