关于特尔比纳耐药三菌种的流行情况的调查 具有烯氧化酶突变的
Yugo Mori1, Tsuyoshi Yamada2, Sayaka Ban1
1Medical Mycology Research Center, Chiba University.
Medical mycology journal
|August 31, 2025
概括
在真菌中,特比纳耐药性正在上升,特别是在T. rubrum以外的Trichophyton物种. 这项研究在日本发现了耐药菌株,揭示了驱动特比纳和醇耐药性的素环氧化酶基因的关键突变.
科学领域:
- 医学真菌学
- 抗菌药物耐药性
- 皮肤植物病的治疗方法
背景情况:
- 特比纳芬 (TBF) 和阿佐尔是皮肤真菌感染的主要治疗方法.
- 全球越来越多的TBF耐药性Trichophyton物种报告,除了Trichophyton rubrum外,其他物种的研究有限.
- 需要了解T. interdigitale,T. mentagrophytes和T. indotineae等研究较少的Trichophyton物种的耐药性.
研究的目的:
- 为了确定日本抗结核菌的Trichophyton分离物的流行.
- 研究这些隔离物中的耐药性机制,包括基因突变.
- 评估与醇抗真菌剂的共抗性模式.
主要方法:
- 来自日本的701个临床Trichophyton分离物的查.
- 确定TBF的最小抑制度 (MIC).
- 测序氧化酶基因以确定与TBF耐药性相关的突变.
主要成果:
- 发现了2. 9% (20/ 701) 的抗结核菌株的流行率.
- 耐药的分离物包括T. rubrum,T. interdigitale,T. mentagrophytes和T. indotineae.
- 氧化酶基因的关键突变,特别是Phe397,与高水平的TBF耐药性有关 (MIC≥32μg/ ml).
- 在T. rubrum,T. mentagrophytes和T. indotineae中观察到对醇的同耐药性.
- 检测到一种新型的抗TBF的T.
结论:
- 这项研究强调了日本各种Trichophyton物种出现的TBF耐药性.
- 氧化酶基因的特定突变是TBF耐药性的关键驱动因素.
- 由于抗菌分离物的增加,对TBF和醇抗菌模式的持续监测至关重要.
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