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Updated: Sep 9, 2025

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

Published on: June 4, 2021

[开发一种基于NMR的分子特性平台,用于药物配方的质量评估]

¹Graduate School of Pharmaceutical Sciences, Chiba University.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

|August 31, 2025

概括

核磁共振 (NMR) 光谱是一种分析药物配方的强大工具. 它为优化药物输送,稳定性和溶解提供关键的分子洞察力.

科学领域:

制药科学
分析化学
材料科学

背景情况:

药物配方变得越来越复杂, 需要先进的分析方法.
了解分子特性是优化药物溶解,稳定性和输送的关键.
传统方法往往缺乏分析复杂配方组件的分辨率.

研究的目的:

审查NMR光谱在药物配方研究中的原则和进展.
突出NMR在评估API和辅助剂的物理化学行为方面的能力.
强调NMR在合理配方设计和质量控制中的作用.

主要方法:

使用核磁共振 (NMR) 光谱进行高分辨率的非破坏性分析.
使用像NMR放松计和脉冲场梯度 (PFG) NMR这样的技术.
在现场分析分子移动性,混合性,相互作用和相位行为.

主要成果:

提供关键的分子层面的洞察力.
它可以量化和区分配方中的复杂共存状态.
核磁共振数据与物理稳定性和溶解性等配方属性直接相关.

结论:

核磁共振光谱是制药配方开发和质量控制的必不可少的工具.
它探测分子特性的能力支持药物输送系统的合理设计.
随着药物配方的复杂性增加,NMR的作用将会越来越大.

关键词:

其他国家无形固体分散药物过的情况脂质纳米粒子微乳液分子制药

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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

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相关概念视频

Applications Of NMR In Biology

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.