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Updated: Sep 9, 2025

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
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通过应用基于使用开源PBPK模型预测的血液度的修改因子,估计输静脉TTC (TTCiv)

Tae Hayashi1, Akira Kotaki1, Asako Fukushima1

  • 1Chemicals Assessment and Research Center, Chemicals Evaluation and Research, Institute, Japan (CERI).

The Journal of toxicological sciences
|August 31, 2025
PubMed
概括

这项研究确定了药物可提取物和可浸物 (E&Ls) 静脉内暴露的毒理关注门 (TTCiv). 建议TTCiv为27μg/天/人,有助于患者安全的风险管理.

关键词:
其他静脉注射的TTC没有PDE

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