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通过鱼消费对人类多二暴露的概率方法

Muhammad Zeeshan Jamil¹, Jinrui Zhao¹, Yoshiki Nishi²

¹Department of Mechanical Engineering, Materials Science, and Ocean Engineering, Graduate School of Engineering Science, Yokohama National University.

The Journal of toxicological sciences

|August 31, 2025

概括

这项研究模拟了现实的消费者行为,以估计人们因食用金枪鱼而暴露于多二 (PCB),特别是PCB-153. 这些发现为评估体内污染物的积累提供了更准确的方法.

科学领域:

环境健康
毒理学
药物动力学

背景情况:

对于多双 (PCB) 的传统人类暴露评估通常使用固定的每日或每小时摄入值.
这些固定摄入模型不准确地反映现实世界的典型消费模式,可能导致不准确的暴露估计.

研究的目的:

通过模拟真实的消费者行为,开发和应用一种新的方法来估计人类对PCB-153的暴露.
将模拟摄入数据与基于生理学的药理动力学 (PBPK) 模型相结合,以预测PCB-153随时间的推移而积累.
评估人类对PCB-153的暴露,特别是通过食用金枪鱼.

主要方法:

用一种基于生理学的药理动力学 (PBPK) 模型,在一个假设的女性的6个组织区中模拟PCB-153的积累.
模拟了消费者行为,以确定从金枪鱼中摄入的PCB-153的具体日期和数量.
模拟摄入数据与PBPK模型进行了接触估计.

主要成果:

模拟的PCB-153年摄入量为16313±3797ng/年.
10年后,该模型预测全血中PCB-153的累积度为460±12.6 ng/L.
这些预测度与人类生物监测测量的结果非常相匹配.

结论:

这项研究提出了一种有前途的,更现实的方法来评估人类对食品带来的污染物,如PCB.
这些发现强调了在暴露评估中考虑可变的消费模式的重要性.
这种方法可以为与饮食接触污染物相关的公共卫生政策提供信息.

关键词:

饮食摄入量人类暴露在PCB-153中基于生理学的药物动力学模型概率风险评估鱼的消费

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