来自各种加热烟草产品的主流烟雾中的活性氧物种的确定
Shoichi Nishimoto-Kusunose1, Yohei Inaba1, Kanae Bekki1
1Department of Environmental Health, National Institute of Public Health.
Environmental health and preventive medicine
|August 31, 2025
概括
加热的烟草产品产生反应性氧物种 (ROS),导致氧化应激. 用户可能会吸入比通常在城市空气中发现的更多的ROS,造成潜在的健康风险.
科学领域:
- 环境健康
- 毒理学
- 呼吸系统医学
背景情况:
- 全球吸烟率正在下降, 但加热烟草产品 (HTP) 越来越受欢迎, 特别是在日本.
- 反应性氧物种 (ROS) 导致氧化应激,与癌症和心血管问题等吸烟相关的疾病有关.
- 关于HTP常规烟雾中ROS含量的数据有限.
研究的目的:
- 量化各种HTP设备的主要烟雾产生的ROS量.
- 评估与HTP使用相关的潜在氧化应激毒性.
主要方法:
- 从IQOS ILUMA,glo hyper+和Ploom X ADVANCED采集了主流烟雾,使用的是加拿大卫生部的强化方案.
- 采集的ROS使用2,7'-二二烯酸试剂进行量化.
- 通过光强度测量过氧化 (H2O2) 的含量.
主要成果:
- 根据HTP设备的ROS水平有所不同:IQOS ILUMA (48. 8±8. 6),高温glo hyper+ (86. 6±12. 6) 和Ploom X ADVANCED (40. 8±5. 7nmol H2O2/棒).
- 在高温模式下,Glo hyper+产生的ROS明显高于标准模式.
- 每日使用HTP (20根棒) 可能会导致ROS暴露比城市大气水平高2.2-96倍.
结论:
- 可以证明,反应性氧物种 (ROS) 是来自不同加热烟草产品 (HTP) 的常规烟雾产生的.
- 与正常日常环境暴露相比,HTP使用者可能面临显著增加的ROS暴露.
- 这些发现突出了与高酸消费相关的潜在氧化应激健康风险.
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