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巴西绿色通过两种不同的途径调节热生成
Takuma Hyodo1, Nobuaki Okumura1, Takanori Tsuda2
1Institute for Bee Products and Health Science, Yamada Bee Company Inc.
Journal of nutritional science and vitaminology
|August 31, 2025
概括
巴西绿色 (BGP) 激活了两个不同的热生成途径. 库利福林是一种BGP成分,通过TRPV1刺激棕色脂肪组织 (BAT) 热生成,而Artepillin C则促进色脂肪细胞的形成,从而增加能量消耗.
科学领域:
- 代谢研究
- 脂肪组织生物学
- 自然产品化学
背景情况:
- 巴西绿色 (BGP) 加快新陈代谢并诱导色脂肪细胞.
- 亚特皮林C (ArtC) 是一种关键的BGP化合物,促进白色脂肪组织的色脂肪细胞形成和热生成.
- BGP对色脂肪细胞的形成和能量代谢的确切机制需要进一步阐明.
研究的目的:
- 研究BGP对色脂肪细胞形成和热生成的影响.
- 确定负责这些影响的特定BGP组件.
- 阐明参与BGP中介热生成的分子途径.
主要方法:
- 在体外细胞培养和分化试验.
- 包括组件测试和热生成测量在内的体内研究.
- 针对TRPV1通道的流量测定和抑制性研究.
主要成果:
- 证实Artepillin C (ArtC) 是导致色脂肪细胞形成的主要BGP成分.
- 在间棕色脂肪组织 (iBAT) 中,BGP诱导的热生成并非由ArtC介导.
- 另一种BGP衍生物库利福林被确定为通过TRPV1交感神经系统途径激活IBAT热生成,增加IBAT温度类似于BGP.
结论:
- BGP独特地激活了两个单独的热生成途径:色脂肪细胞形成 (通过ArtC) 和棕色脂肪细胞热生成 (通过culifolin).
- 库利福林在iBAT中激活TRPV1信号,对BGP的发热效应有显著的贡献.
- BGP通过涉及棕色和色脂肪组织的独特机制提高了能量消耗.
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