质血流对子宫内孕激素度和日本黑牛的基因表达的影响
Tomomi Kanazawa1, Motohide Seki2, Kosuke Iga3
1Cooperative Department of Veterinary Medicine, School of Veterinary Medicine, Iwate University, Iwate 020-8550, Japan.
The Journal of reproduction and development
|August 31, 2025
概括
乳腺血流影响牛子宫内膜基因表达,影响生育能力. 这项研究发现,在第7天,较高的白色血管性改变了特定的基因水平,而没有改变孕激素度.
科学领域:
- 生殖生物学
- 牛内分泌学
- 基因组学
背景情况:
- 黄体血流 (LBF) 对于黄体 (CL) 中的孕激素产生至关重要,影响牛的生育能力.
- 目前尚不完全了解LBF对生育能力的影响机制.
研究的目的:
- 在日本黑牛中研究LBF对子宫内孕激素度和基因表达的影响.
- 阐明白色血管和影响生育的子宫环境之间的关系.
主要方法:
- 卵巢活检和血液样本从13头母牛收集在第7天后.
- 根据LBF,奶牛被分为低 (LV),中等 (MV) 和高血管性 (HV) 组.
- 测量了血和子宫内孕激素水平;使用RNA测序和RT- qPCR进行基因表达分析.
主要成果:
- 在LV和HV组之间没有发现血或子宫内膜孕激素度的显著差异.
- 鉴定出CCN3是一种差异表达的基因,在HV组上调.
- 与LV组相比,HV组显示出更高的CCN3和PGRmRNA,以及更低的ANPEP,DGAT2和DKK1mRNA.
结论:
- 乳腺血流在牛乳周期的第7天显著影响子宫内膜基因表达.
- 这些变化与总体孕激素水平的变化无关.
- 了解这些基因表达模式可能有助于了解LBF在牛生育中的作用.
相关概念视频
01:27Ovarian Cycle
1.8K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.8K
01:22Hormonal Regulation of the Menstrual Cycle
688
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
688