在中国儿童中,血压轨迹与高动脉内膜厚度之间的关联
Chongran Ma1, Xiaoyun Ma1, Min Zhao2
1Department of Epidemiology, Health Management Center, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 31, 2025
概括
患有静脉血压升高的儿童患上高动脉内膜厚度 (cIMT) 的几率增加. 监测SBP变化和使用性别特定的策略对于预防高cIMT至关重要.
科学领域:
- 儿童心脏病学
- 血管健康
- 生物统计学
背景情况:
- 儿童血压 (BP) 轨迹及其与动脉内膜厚度 (cIMT) 的联系仍未得到充分研究.
- 儿童的高cIMT是心血管风险的早期指标.
研究的目的:
- 在儿童中识别血压 (BP) 的不同轨迹.
- 研究这些BP轨迹与高动脉内膜厚度 (cIMT) 的可能性之间的关联.
主要方法:
- 在6年的随访期间,利用了1175名儿童 (6-11岁) 的纵向数据的基于小组的轨迹建模 (GBTM).
- 分析了系统血压 (SBP) 和透气血压 (DBP) 的轨迹.
- 评估了高cIMT相对于确定BP轨迹组的概率.
主要成果:
- 对SBP (低,中,高) 和DBP (低,中,高) 确定了三个不同的轨迹组.
- 与"低"SBP组相比",中"和"高"SBP轨迹组的儿童显示出高cIMT的几率明显更高.
- 性别分析显示"中"和"高"SBP组中的女孩和"高"SBP组中的男孩的高cIMT概率. 在DBP轨迹和高cIMT之间没有发现显著的关联.
结论:
- 在儿童时期的静脉血压 (SBP) 轨迹与高动脉内膜厚度 (cIMT) 的发展有关.
- 这些发现强调需要对儿童的SBP变化进行警监测.
- 针对儿童群体预防高cIMT的干预措施,建议采用性别特定的方法.
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