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Updated: Sep 9, 2025

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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制药纳米晶体的发展:一个全面的审查

Apexa M Shah1

  • 1Department of Pharmaceutics, Gandhinagar institute of Pharmacy, Gandhinagar University, India.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
|August 31, 2025
PubMed
概括

难以溶解的化合物从颗粒大小的减少中受益. 纳米化将微小化的颗粒转化为纳米颗粒,提高药物的生物可用性和治疗效果,以更好地向疾病.

关键词:
生物可用性从下而上纳米晶体可溶性较差从上到下

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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