阴道微生物与妇科症状的相关性,亲密卫生做法和IVF患者的背景参数:横截面研究
Thor Haahr1,2, Sophie Ovesen3,4, Nina la Cour Freiesleben5,6
1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. thohaa@rm.dk.
Journal of assisted reproduction and genetics
|August 31, 2025
概括
在IVF患者中,阴道失生很常见,通常没有症状. 它与更高的BMI和浴等私密卫生做法有关, 这可能会对生殖健康产生负面影响.
科学领域:
- 生殖医学
- 微生物组研究
- 女性健康
背景情况:
- 由阴道微生物群不平衡所表现的阴道失生症越来越多地被认为是影响生殖结果的因素.
- 了解经过体外受精 (IVF) 的女性阴道失生症的患病率和相关因素对于优化治疗和提高成功率至关重要.
研究的目的:
- 在IVF患者的基线参数和阴道亲密卫生习惯进行比较.
- 在该患者群体中确定与阴道失调相关的危险因素.
主要方法:
- 一项涉及1511名试管婴儿患者的横截面研究.
- 使用定量聚合酶链反应 (qPCR) 确定阴道失生状态. 和/或Fannyhessea vaginae,以及16S rRNA基因测序 (VALENCIA).
- 通过问卷和采访收集了基线参数和私密卫生习惯的数据,并计算了流行率 (PR).
主要成果:
- 阴道失调的患病率是34%通过qPCR和32%通过社区类型IV测序.
- 较高的BMI (25 - 30和> 30) 和有鱼味的存在与阴道失调的患病率显著增加有关.
- 阴道洗非常普遍 (PR 1. 31),与阴道失调有显著的相关性,女性报告其用于感知清洁.
结论:
- 在试管婴儿患者中,阴道失生症是一种普遍的,往往是临床前的疾病.
- 生活方式因素,包括体重指数升高和浴等特定的私密卫生习惯, 与阴道失调有显著的联系.
- 这些发现凸显了在辅助生殖技术的背景下解决阴道健康和卫生问题的重要性.
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