Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

377
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
377
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

75
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
75
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

717
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
717
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

2.0K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.0K
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

315
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
315
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

23
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
23

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Design of the OverCool study: Lung-conservative liquid ventilation for the induction of Ultra-Rapid Cooling after Cardiac Arrest (OverCool).

Resuscitation plus·2025
Same author

Association of age with extubation failure in neurocritical intensive care unit patients--Insight from an international prospective study named ENIO.

Journal of critical care·2025
Same author

A consensus of European experts on the definition of ventilator-associated pneumonia recurrences obtained by the Delphi method: the RECUVAP study.

Intensive care medicine·2025
Same author

Recovery Potential in Patients After Cardiac Arrest Who Die After Limitations or Withdrawal of Life Support.

JAMA network open·2025
Same author

Alterations in the renin-angiotensin system during septic shock.

Annals of intensive care·2025
Same author

Management of severe acute encephalopathy in the ICU: an expert consensus statement from the french society of intensive care medicine.

Annals of intensive care·2025
Same journal

Mouse models to study von Willebrand factor in inflammation: a scoping review.

Intensive care medicine experimental·2026
Same journal

Confocal laser endomicroscopy in patients with acute respiratory failure.

Intensive care medicine experimental·2026
Same journal

Source-controlled bacterial peritonitis improves survival but leaves persistent lung inflammation and airway IgA loss.

Intensive care medicine experimental·2026
Same journal

Noradrenaline-trajectory phenotypes in septic shock: derivation and external validation in two independent cohorts.

Intensive care medicine experimental·2026
Same journal

Exploratory dose modeling of hemoadsorption in pediatric septic shock.

Intensive care medicine experimental·2026
Same journal

Sex-related differences in lung injury distribution and outcomes in COVID-19 acute respiratory failure: insights from the CT-COVID19 multicenter study group.

Intensive care medicine experimental·2026
查看所有相关文章

相关实验视频

Updated: Sep 9, 2025

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

18.4K

多布胺的使用:一种标准化方法的建议

Lorenzo Calabró1, Filippo Annoni2, Fabio Silvio Taccone2

  • 1Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, 1070, Brussels, Belgium. l.calabro@hubruxelles.be.

Intensive care medicine experimental
|August 31, 2025
PubMed
概括
此摘要是机器生成的。

这项研究提出了在重症患者中使用多布他的框架. 它强调明确的指示和持续的监测以优化心脏收缩性和改善患者的结果.

关键词:
心脏输出多布他胺血液动力学监测器官功能障碍冲击组织输液

更多相关视频

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

3.7K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.2K

相关实验视频

Last Updated: Sep 9, 2025

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

18.4K
Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

3.7K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.2K

科学领域:

  • 危急护理医学
  • 心脏病学
  • 药理学

背景情况:

  • 多布胺是危急心脏收缩能力受损的患者常见的异能药物.
  • 它的益处与风险是有争议的, 缺乏对其使用的结构性指导.

研究的目的:

  • 在临床和实验环境中提出多布他的实用框架.
  • 确保在心脏输出量低的休克中合理和一致地使用多布他明,包括心脏性休克,败血症休克和心脏输出量低综合征 (LCOS).

主要方法:

  • 杜布他胺应用于急性循环衰竭与低输血和心脏收缩能力受损;单独的低心脏指数是不够的.
  • 对初步评估至关重要,辅以持续的心脏输出监测来评估剂量反应.
  • 一种标准化的方法涉及2.5μg/ kg/ min的起始剂量,并根据心脏指数和 perfusion 标记每20分钟进行逐步定位.

主要成果:

  • 随着心脏指数的显著增加和低输液的解决,应引导多布他剂量的升级.
  • 尽管心脏指数有所改善,但持续的低输血表明反应不足,因此需要谨慎增加剂量.
  • 随着心脏指数的进一步上升,持续的低输血表明了流量独立的缺陷,阻止了进一步的定位.

结论:

  • 多布他的使用需要明确的指示和标准化的方法,包括连续的血液动力学和 perfusion 监测.
  • 这一策略旨在优化治疗效益,同时最大限度地减少不必要的暴露和不良影响.
  • 拟议的框架促进了在重症监护机构的合理和可重复的内疗法.