免疫受损儿童中与死亡相关的因素
Asri Kartika Putri1,2, Pudjo Hagung Widjajanto1, Eggi Arguni3
1Department of Child Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Jalan Farmako, Sekip Utara, Yogyakarta, Sleman, 55281, Yogyakarta, Indonesia.
对于免疫力低下的儿童来说,水是危险的. 多重并发症和高中性粒细胞/ 淋巴细胞比率 (NLR) 显著增加了这一易受感染群体的水死亡风险.
科学领域:
- 儿童传染病
- 免疫学
- 流行病学
背景情况:
- 与免疫能力较强的个体相比,水是免疫功能低下的儿童的一个重大问题,其患病率和死亡率的风险更高.
- 全民健康覆盖战略旨在对抗诸如天花之类的疫苗可预防疾病.
- 这项研究调查了在印尼的一个中心免疫力低下的儿童中与水相关的死亡因素.
研究的目的:
- 在免疫功能低下的儿科患者中分析与水相关死亡率相关的因素.
- 在印度尼西亚Sardjito总医院发现小儿童死亡的危险因素.
主要方法:
- 在2017年1月至2022年12月期间被诊断患有水的免疫受损儿科患者的回顾性分析.
- 使用双变量分析来确定与死亡相关的因素.
主要成果:
- 在74名住院的水患者中,有63名 (85%) 免疫功能低下,主要是血性恶性瘤 (57%).
- 没有患者接种了天花疫苗. 20名患者 (32%) 出现并发症,最常见的是肺炎 (12. 7%).
- 在6名 (9. 5%) 患者中发生了与水相关的死亡. 死亡率与≥2种水并发症 (RR 23. 64) 和中性粒细胞/ 淋巴细胞比率 (NLR) >3. 3 (p=0. 047) 有关.
结论:
- 多种水并发症是免疫受损儿童死亡的主要危险因素.
- 中性粒细胞/ 淋巴细胞比率 (NLR) 大于3. 3与该患者群体的死亡风险显著增加有关.
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