自闭症患者在一生中的皮层下大脑体积变化
Danielle Christensen1,2, Young Seon Shin2,3, Jingying Wang1,2
1Neurocognitive and Behavioral Development Laboratory, University of Florida, 1864 Stadium Road, 146 FLGym, PO Box 118205, Gainesville, FL, 32611-8205, USA.
Molecular autism
|August 31, 2025
概括
自闭症谱系障碍 (ASD) 呈现出明显的大脑衰老模式,随着心室的扩大和皮下体积的改变. 这些发现表明潜在的神经退行症,并突出了未来ASD干预的目标.
科学领域:
- 神经科学
- 发展心理学
- 放射学
背景情况:
- 皮质下大脑区域的变化 (杏仁体,海马体,基底,心室) 与自闭症谱系障碍 (ASD) 的特征有关.
- 自闭症中这些区域的体积变化仍未得到充分研究.
研究的目的:
- 研究自闭症和神经类型个体在皮质下大脑区域的年龄相关体积差异.
- 检查两个群体在整个生命周期内这些区域的结构性相互关系.
主要方法:
- 分析了来自119名自闭症患者和122名神经类型患者 (7-73岁) 的多部位T1权重MRI数据.
- 使用ComBat和提取主要组件分数的统一体积数据.
- 区域体积的比较和不同年龄组之间的相互关系.
主要成果:
- 自闭症患者早期的桃体和海马体容量较大, 随着年龄的增长,
- 自闭症组呈现出始终较大的基底和加速的大脑心室扩大.
- 在自闭症成年人中,心室与周围区域之间的逆体积相关性更为明显,表明早期/广泛的缩.
结论:
- 自闭症和神经类型个体之间存在不同的与年龄相关的皮质下体积模式.
- 在晚年,心室加速膨胀和区域间关系的改变可能表明ASD的异常大脑衰老和缩.
- 皮下区域可以作为神经退行症的生物标志物和整个生命周期的自闭症干预的目标.
相关概念视频
01:19Autism Spectrum Disorder
335
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
335
01:30Biological Influences on Intelligence
213
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
213