九种用于预测心血管疾病的胰岛素耐药替代品的比较:一项队列研究
Haoqi Zhou1, Yu Shi2, Xiaohua Zhou3,4
1Department of Biostatistics, School of Public Health, Peking University, 38 Xueyuan Rd, Haidian District, Beijing, 100191, China.
Diabetology & metabolic syndrome
|August 31, 2025
概括
在中国成年人的9个胰岛素抵抗指标中,甘油三糖 (TyG) 指数最能预测心血管疾病 (CVD) 风险. 这种简单的措施为早期心脏病风险评估提供了强有力的工具.
科学领域:
- 心脏病学
- 代谢综合征研究
- 公共卫生
背景情况:
- 胰岛素抵抗 (IR) 是已知的心血管疾病 (CVD) 的风险因素.
- 存在几种简单的IR指标,但它们对预测心血管疾病的比较能力尚未得到充分证实.
- 本研究研究了9个IR替代指标对中国人群中发生的心血管疾病的预测效用.
研究的目的:
- 评估九个IR替代指标和发生的心血管疾病之间的关联.
- 通过比较评估这些IR替代品对心血管疾病的预测能力.
- 确定在中国成年人中早期预测心脏病风险的最有效的IR替代品.
主要方法:
- 在中国健康与退休长度研究 (CHARLS) 中使用了7662名没有心血管疾病的参与者的数据.
- 计算了九个IR替代指标:甘油三指数 (TyG),TG/HDL比,METS-IR,CVAI,LAP,AIP,TyG-BMI,TyG-WC和TyG-WHtR.
- 使用Cox和受限制的立方线模型来分析关系,并使用C指数来比较在8.2年后续的预测性表现.
主要成果:
- 所有9个IR指标都与心血管疾病风险的增加有显著关联.
- 三甘油糖 (TyG) 指数显示出最高的预测性能,C指数为0. 742.
- 在随访期间,该研究观察到1906例心血管病例.
结论:
- 在九种评估的替代品中,甘油三糖 (TyG) 指数是预测中年和老年人心血管疾病的最有效指标.
- TyG指数是早期心血管疾病风险分层的简单,有效和临床可用的工具.
- 这些发现支持TyG指数对主动心血管健康管理的临床实用性.
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