牙周炎中的心血管生物标志物:系统审查和元分析
Vandana Gupta1, Anika Dawar1, Sumit Kumar Das2
1Division of Periodontics, Centre for Dental Education & Research, All India Institute of Medical Sciences, New Delhi, India.
Oral diseases
|September 1, 2025
概括
牙周炎与心血管疾病有关. 血中的高密度脂蛋白 (HDL) 降低和氧化应激指数 (OSI) 增加是潜在的生物标志物,尽管证据的确定性很低.
科学领域:
- 心血管研究
- 牙周病学
- 生物标志物发现
背景情况:
- 牙周炎是一种慢性炎症性疾病,与全身性疾病,特别是心血管疾病 (CVD) 有着越来越多的联系.
- 确定可靠的生物标志物对于理解和管理牙周炎与心血管疾病之间的联系至关重要.
- 血液,唾液和牙裂液 (GCF) 等生物流体是这些生物标志物的潜在来源.
研究的目的:
- 系统地审查和综合有关牙周炎的心血管生物标志物的证据.
- 在血液,唾液和GCF中确定特定的生物标志物,这些生物标志物在牙周炎患者和健康个体之间显示出显著的差异.
- 使用GRADE工具评估已识别的生物标志物的证据确定性.
主要方法:
- 在五个数据库中进行了全面的文献搜索,包括到2024年12月31日发表的研究.
- 对每种生物流体至少两项研究中发现的生物标志物进行了分析.
- 使用敏感性分析和GRADE评估来评估结果的稳定性和确定性.
主要成果:
- 包括36项研究,其中31项对分析做出了贡献,在血液,唾液和GCF中确定了39个独特的生物标志物.
- 在牙周炎患者的血液中,分析显示高密度脂蛋白 (HDL) 显著降低,氧化应激指数 (OSI) 升高.
- 其他一些常被研究的生物标志物,包括C反应蛋白 (CRP),在此元分析中没有显著的关联,特别是在唾液和GCF中.
结论:
- 血中HDL降低和OSI升高被认为是牙周炎的潜在心血管生物标志物.
- 目前支持这些生物标志物的证据的确定性很低,因此需要进一步进行高质量的研究.
- 需要进一步的研究来验证这些发现,并澄清牙周炎与心血管健康之间的病因联系.
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