最近的癌症与自杀之间的关联:丹麦国家队列研究
Cecilie Fitzgerald1,2, Susanne Oksbjerg Dalton3,4,5, Henrik Frederiksen6
1Danish Research Institute for Suicide Prevention, Mental Health Centre Copenhagen, Copenhagen, Denmark.
The British journal of psychiatry : the journal of mental science
|September 1, 2025
概括
癌症诊断与增加自杀风险有关,特别是在诊断后的六个月内. 胰腺癌和食道癌的发病率最高,
科学领域:
- 癌症学
- 公共卫生
- 精神病学
背景情况:
- 癌症诊断是一个重要的压力因素,
- 目前还没有对各种癌症类型的自杀率进行全面比较.
研究的目的:
- 与一般人群相比, 在过去五年内诊断出患有癌症的个体中, 自杀率较高.
- 分析自杀率,癌症诊断后的时间,癌症阶段和癌症部位之间的联系.
主要方法:
- 一项基于人口的队列研究,使用来自丹麦的全国纵向数据 (2000-2021年),针对15岁以上的个人.
- 作为结果,研究了自杀,首次癌症诊断 (特定部位) 作为五年内的暴露.
- 使用波桑回归来计算调整的发病率比率 (aIRRR),控制社会人口统计学,精神疾病和先前的自杀企图.
主要成果:
- 这项研究包括707513名患者;601名癌症患者因自杀而死亡,而非癌症组的患者为12800人,调整后发病率比率 (aIRR) 为2. 0.
- 自杀率在诊断后的六个月内最高 (aIRR=3. 9),随着时间的推移 (4-5年:aIRR=1. 8).
- 高阶段瘤 (aIRR=3. 1) 和胰腺 (aIRR=7. 5) 和食道 (aIRR=7. 1) 等特定癌症显著增加了自杀率.
结论:
- 新确诊的癌症与自杀率的增加有关,特别是在诊断后的最初时期.
- 瘤高发期和预后不佳的癌症部位与最高的自杀率有关.
- 这些发现表明,对于高风险的癌症诊断和癌症阶段患者,应优先考虑预防自杀的努力.
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