基于LED的混合扩散反射光谱法在盲目的多中心研究中确定SPF和UVA-PF (ALT-SPF)

相关实验视频

Updated: Sep 9, 2025

Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

Published on: June 6, 2017

Carina Reble^1,2, Michael Bayer³, Bertrand Colson⁴

¹Courage + Khazaka electronic GmbH, Cologne, Germany.

International journal of cosmetic science

|September 1, 2025

概括

一种新的非侵入性LED-HDRS方法有望确定太阳保护因子 (SPF) 和UVA保护因子 (UVA-PF),其结果与当前的黄金标准相当,为防晒测试提供了可行的替代方案.

科学领域:

皮肤学和光生物学
分析化学
美容科学

背景情况:

根据ISO 24444:2019,目前基于红斑的阳光保护因子 (SPF) 测试存在局限性.
正在探索非侵入性方法作为传统的SPF测试的替代方法.
为了评估这些替代方法,ALT-SPF联盟进行了一项国际循环测试.

研究的目的:

描述非侵入性方法作为基于红斑的SPF测试的替代方法.
评估混合扩散反射光谱 (HDRS) 在体内确定SPF和UVA保护因子 (UVA-PF) 的性能.
将HDRS方法与已确定的参考方法进行比较 (ISO 24444和ISO 24443).

主要方法:

采用混合扩散反射光谱 (HDRS),使用多lambda的LED光源.
在皮肤上测量体内反射光谱,并与薄膜的体内吸收光谱融合.
一项盲目的研究涉及四个欧洲实验室,随后通过改进的方法进行了重新评估.
使用统计验收标准将HDRS结果与SPF和UVA-PF的参考方法进行比较.

主要成果:

最初的研究显示可接受的偏差,但需要提高可重现性和实验室间的可变性.
重新评估研究显示可重复性和实验室间变异性显著改善.
在重新评估研究中,SPF结果接近接受标准,UVA-PF结果在很大程度上处于限制范围内.
经过改进后,HDRS方法的精度与黄金标准方法 (ISO 24444和ISO 24443) 相同.

结论:

LED-HDRS方法提供了合理的非侵入性SPF和UVA-PF结果.
LED-HDRS方法的性能与参考方法密切一致.
建议使用LED-HDRS方法作为现行ISO 24444和ISO 24443标准的可行替代品.

关键词:

要求的证据乳液光谱学统计数据阳光保护因子紫外线A保护因子

更多相关视频

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Published on: January 29, 2020

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

相关概念视频

UV–Vis Spectrometers

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material, molecules absorb light depending on the energy required for...