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基于LED的混合扩散反射光谱法在盲目的多中心研究中确定SPF和UVA-PF (ALT-SPF)

Carina Reble^1,2, Michael Bayer³, Bertrand Colson⁴

¹Courage + Khazaka electronic GmbH, Cologne, Germany.

International journal of cosmetic science

|September 1, 2025

概括

一种新的非侵入性LED-HDRS方法有望确定太阳保护因子 (SPF) 和UVA保护因子 (UVA-PF),其结果与当前的黄金标准相当,为防晒测试提供了可行的替代方案.

科学领域:

皮肤学和光生物学
分析化学
美容科学

背景情况:

根据ISO 24444:2019,目前基于红斑的阳光保护因子 (SPF) 测试存在局限性.
正在探索非侵入性方法作为传统的SPF测试的替代方法.
为了评估这些替代方法,ALT-SPF联盟进行了一项国际循环测试.

研究的目的:

描述非侵入性方法作为基于红斑的SPF测试的替代方法.
评估混合扩散反射光谱 (HDRS) 在体内确定SPF和UVA保护因子 (UVA-PF) 的性能.
将HDRS方法与已确定的参考方法进行比较 (ISO 24444和ISO 24443).

主要方法:

采用混合扩散反射光谱 (HDRS),使用多lambda的LED光源.
在皮肤上测量体内反射光谱,并与薄膜的体内吸收光谱融合.
一项盲目的研究涉及四个欧洲实验室,随后通过改进的方法进行了重新评估.
使用统计验收标准将HDRS结果与SPF和UVA-PF的参考方法进行比较.

主要成果:

最初的研究显示可接受的偏差,但需要提高可重现性和实验室间的可变性.
重新评估研究显示可重复性和实验室间变异性显著改善.
在重新评估研究中,SPF结果接近接受标准,UVA-PF结果在很大程度上处于限制范围内.
经过改进后,HDRS方法的精度与黄金标准方法 (ISO 24444和ISO 24443) 相同.

结论:

LED-HDRS方法提供了合理的非侵入性SPF和UVA-PF结果.
LED-HDRS方法的性能与参考方法密切一致.
建议使用LED-HDRS方法作为现行ISO 24444和ISO 24443标准的可行替代品.

关键词:

要求的证据乳液光谱学统计数据阳光保护因子紫外线A保护因子

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