沙特阿拉伯的代谢功能障碍相关的脂肪性肝病管理:根据国际标准的德尔菲修改
Faisal Abaalkhail1,2, Faisal M Sanai2, Khalid AlSwat3
1College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
概括
沙特专家制定了与代谢功能障碍相关的脂肪性肝病 (MASLD) 和代谢功能障碍相关的脂肪性肝炎 (MASH) 的指导方针. 建议侧重于使用非侵入性测试和多学科管理策略的早期检测,以获得更好的患者结果.
科学领域:
- 肝病学和胃肠病学
- 代谢疾病
- 临床实践指南
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 现在是代谢功能障碍相关的脂肪性肝病 (MASLD).
- 代谢障碍在沙特阿拉伯普遍存在,需要本地化MASLD/MASH指导.
- 现有的指导方针需要根据沙特人口的具体需求进行调整.
研究的目的:
- 为沙特阿拉伯的 MASLD/MASH 制定专家共识建议.
- 引导早期发现,专家转诊和管理策略.
- 为了解决与代谢功能障碍相关的肝硬化病的重新分类和日益增长的患病率.
主要方法:
- 修改了15个多学科专家的德尔菲过程.
- 使用推评级,评估,发展和评估标准进行文献审查 (2011-2024年).
- 确定的查标准,风险分层门和治疗途径.
主要成果:
- 使用非侵入性测试 (如FIB-4,ELF和MRE) 确立了高风险组的查标准.
- 已定义的风险值:FIB-4≥2. 67,LSM>12kPa,MRE>5. 0kPa对于晚期纤维化转诊.
- 建议采用多学科方法,包括改变生活方式,药物治疗 (GLP- 1 RA,SGLT2抑制剂,皮奥格利塔) 和减肥手术.
结论:
- 为沙特阿拉伯的MASLD/MASH管理提供基于证据的指导.
- 通过NIT和风险分层护理强调早期检测.
- 强调多学科治疗对于改善患者结果的重要性.
相关概念视频
01:29Chronic Pancreatitis II: Collaborative Care
128
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
128
01:26Diseases of the Liver and Gallbladder
965
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
965
01:30Liver Physiology
1.1K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
1.1K