使用UCLA GIT 2.0评估对青少年系统性硬化症的胃肠道影响和工具性能
Sophie Stefancic1, Amanda Robinson2,3, Haley J Havrilla2
1University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
在幼儿系统性硬化症 (jSSc) 中,UCLA GIT 2.0 有效测量胃肠道 (GI) 问题,对儿科患者显示出良好的有效性和响应性. 这种工具有助于在研究和临床环境中跟踪胃肠道结果.
科学领域:
- 儿童风湿病学
- 胃肠病学
- 临床结果评估
背景情况:
- 青少年发作的全身性硬化症 (jSSc) 经常涉及胃肠道 (GI) 的并发症.
- 准确的评估工具对于监测小儿SSc患者的胃肠道症状至关重要.
研究的目的:
- 在jSSc中使用UCLA硬皮病临床试验联盟胃肠道2.0 (UCLA GIT 2.0) 仪器来描述胃肠道症状.
- 在儿童SSc群体中评估UCLA GIT 2.0的有效性和响应能力.
主要方法:
- 使用了来自儿童发病性硬化症国家注册表的51名患者的数据.
- 对SHAQ-GI-VAS和SHAQ-DIS-VAS进行了评估.
- 在一年内使用对对评估来探索反应能力.
主要成果:
- 平均UCLA GIT2. 0总得分为0. 30,表示轻微的胃肠道负担.
- 最常见的胃肠道症状是膨胀/ 膨胀和反流 (> 70% 的患者).
- 该仪器与其他措施 (支持有效性) 有显著的相关性,并且随着时间的推移显示出改善 (表明响应能力).
结论:
- 美国加州大学洛杉矶分校的GIT 2.0是评估jSSc的胃肠道症状的有效和敏感工具.
- 该仪器适用于在研究和临床实践中监测儿科胃肠道疾病的结果.
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